Preprint: Trends and patterns of sedative prescribing in primary care in Ireland between 2014 and 2022 – a repeated cross-sectional study
Our latest study on drug utilisation analyses both trends in the volume of sedative drug prescribing, and also prescribing patterns in relation to prevalence of use, initiations and discontinuations, and high risk prescribing. This study uses data from Ireland provides by the HSE Primary Care Reimbursement Services for people with General Medical Services (GMS) scheme eligibility, and also compares prescribing rate to publicly available data from England.
The paper is currently under review, but a preprint version is now available to read on medRxiv.
Abstract
Background
The trends in sedative use have varied in recent years. Benzodiazepines and z-drugs are indicated for anxiety and sleep disorders, but should be limited to short term use. The aim of this study is to examine trends and patterns in sedative prescribing in Ireland between 2014 and 2022, as well as comparing trends between Ireland and England within the same period.
Methods
Monthly data on medicines prescribed and dispensed in primary care on the means-tested General Medical Services (GMS) scheme in Ireland was used. Volumes of prescribed benzodiazepine and z-drug use and patterns of prescribing, including initiations, discontinuations, chronic use, and high-risk prescribing were summarised per year. Other sedating agents (sedating antihistamines, antidepressants, and antipsychotics) were also analysed. Volume of use outcomes were compared with NHS data from England for the same period.
Results
The rate of benzodiazepine and z-drug dispensings per 1,000 GMS population decreased by 4%, from 1,531 in 2014 to 1,474 in 2022. T By comparison in England, there was a steeper decrease of 27% in the dispensing rate and the level of use was substantially lower, falling from 288 dispensings per 1,000 population in 2014 to 210 in 2022. In Ireland, dispensing rates were highest amongst women and older age groups. High-risk dispensings of benzodiazepines and z-drugs decreased over the study period.
Discussion
Despite decreases in benzodiazepine and z-drug dispensings, rates remain high in Ireland and may suggest a need for enhanced availability of non-pharmacological interventions, and improved education and deprescribing support for healthcare professionals.